Prize Award 1984

“Pharmacokinetic drug interactions in man“

The work “”Pharmacokinetic Drug Interactions in Man”, A theoretical approach and experimental studies”, reports a number of in vivo pharmacokinetic drug-drug interactions. Pharmacokinetic interactions involve changes in the processes of transport of a drug towards and removal from its site of action. Underlying mechanisms such as inhibition of oxidative biotransformation, displacement from protein and inhibition of tubular secretion are described.